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Higher magnificationof cytoplasmic densities attached to the plasma membrane from the area indicated by the rectangle. Long diameter to short diameterratio (LD/SD) of this lesion is 2.5 Long diameter to short diameterratio (LD/SD) of this lesion is 2.5. Upon binding to a speci? c membranereceptor, TGF-beta ligands trigger phosphorylation of SMAD proteins that translocateinto the nucleus and regulate gene expression in combination with other transcriptionfactors and regulators.
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